pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers may well improve the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will lessen the level or result of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabol